Karla Ysabel Marquez Santos (born December 21, 1986), known as Karel Marquez is a Filipino actress, model, singer, and TV host who currently signed under GMA Network. Before joining Kapuso Network, she was part of ABS-CBN Talent Management & Development Center (known as Star Magic). She is a Star Magic Batch 10 alumni.

Marquez started as VJ in Myx, a subsidiary of ABS CBN, in 2003. She was transferred to ABS CBN's rival network, GMA Network, despite being a VJ in Myx as of 2007. She was a member of the cast of GMA's afternoon TV drama Pati Ba Pintig Ng Puso?, where she starred opposite Yasmien Kurdi, JC de Vera, and Chynna Ortaleza among others. She is also a mainstay in GMA's Sunday variety program SOP Rules, where she sings with Kyla, Karylle, Jennylyn Mercado, and Yasmien Kurdi. She also presently hosts a segment of GMA's gag show Bitoy's Funniest Videos entitled "Just 4 Kikays". She has a role in an upcoming GMA primetime, Zaido, as Lyka. She has been one half of the covergirls in the November 2006 edition of FHM Philippines, along with Amanda Griffin. Karel, along with Drew Arellano, is also a co-host in Coca Cola: Ride To Fame, a reality talent show after SOP Rules. She has given a role in an upcoming GMA primetime, Zaido. She's also a radio DJ.

She's a daughter of Pinky Marquez, who is also an actress, model and singer and Dr. Eduardo Santos. She has also two siblings.